Ovarian rejuvenation is a technique used in regenerative medicine, through which we obtain a series of cells—platelets—that, when injected into the ovary, may help activate primordial follicles that are dormant in the ovary.
Ovarian regeneration aims to stimulate the ovarian environment and promote ovarian response through the use of regenerative techniques such as platelet-rich plasma (PRP).
The goal of the technique is to improve the quality of the patient’s eggs for assisted reproduction treatment and achieve better results.
The application of platelet-rich plasma (PRP) is a regenerative therapeutic practice that efficiently repairs deteriorated or damaged tissues. In reproductive medicine, it offers great benefits, as it is obtained from the patient's own blood by centrifugation.
When activated, it triggers processes that release growth factors (GFs) that stimulate the body's mechanisms for repairing damaged or deteriorated tissues, favouring ovarian repair and rejuvenation.
The process of obtaining the sample is simple. Blood is collected from the patient. It is then processed in the laboratory by controlled centrifugation to separate the plasma containing the platelets from the rest of the blood components.
Once it is obtained, it is administered to the area to be treated, either the endometrium or the ovary. For ovarian rejuvenation, small amounts of the sample are injected into the ovarian cortex via transvaginal ovarian puncture.
A blood sample is collected from the patient to obtain the plasma that will be used during the procedure.
The blood sample is centrifuged to separate and obtain plasma with a high concentration of platelets. The platelets contain growth factors that can subsequently be released and used during the procedure.
The platelets release different growth factors and other bioactive molecules. Once the plasma has been prepared, it can be administered into the ovary with the aim of promoting the response of the ovarian tissue.
The prepared plasma is administered according to the indications of our specialists and the individual characteristics of each patient.
Delayed childbearing is a factor that affects women biologically, especially from the age of 35 onwards. From this age onwards, a greater number of eggs are lost. With ovarian rejuvenation, we increase the chances of achieving good results in reproductive treatments. However, it could also potentially improve the chances of natural pregnancy.
Ovarian rejuvenation has several advantages over other techniques:
A growing body of data confirms the effectiveness of these techniques on both the endometrium and the ovary.
The use of the patient's PRP minimises the risk of allergic reactions, infections and other complications.
Although these techniques are relatively new, they are increasingly integrated into the treatment flow at fertility clinics. This allows more data to be collected and their use to be fine-tuned.
Among the most promising results is the reactivation of ovarian follicles. This could increase the pregnancy rate in women with early ovarian failure or low ovarian reserve.
Results can vary from one patient to another and depend on factors such as age, initial ovarian reserve and the clinical characteristics of each case. Some studies have observed changes in certain markers related to ovarian function, such as anti-Müllerian hormone (AMH) levels, the antral follicle count or the response to ovarian stimulation.
However, these changes do not occur in all patients and do not guarantee an improvement in fertility or the chances of pregnancy. For this reason, progress should be assessed individually through medical follow-up and by comparing the parameters obtained before and after treatment.
The aim of ovarian rejuvenation techniques is to try to improve ovarian function and promote ovarian activity in certain patients. Although some studies have observed changes in markers of ovarian activity, it cannot currently be stated that these techniques permanently reverse menopause.