Rejuvenecimiento ovárico y uterino

Regenerative medicine and fertility – or how endometrial and ovarian rejuvenation therapies can help to achieve pregnancy

If we were to look up what reproductive medicine is, we would roughly understand it to be the branch of health that, in dealing with human reproduction, is focused on the study of the creation of life itself. While this is true, one should not overlook another aspect that characterises it: its ability to provide the best results when it draws on other specialties. 

This is the case with regenerative medicine and, in particular, with the application of platelet-rich plasma (PRP), which, since its first use in 1987, has become a biological material of broad therapeutic scope in branches such as traumatology, neurosurgery and, in recent years, reproductive medicine too. 

Platelet-rich plasma: origin and benefits

The definition of PRP is mainly based on two of its properties, the first being its autologous origin, i.e. it comes from the same person to whom it is subsequently administered. Secondly, it is essential to understand the capacity that makes it special, which is its ability to regenerate tissue. Its vasoactive substances promote cell proliferation, which will ultimately bring about tissue repair and rejuvenation. 

In reproductive medicine, platelet-rich plasma can improve ovarian and endometrial function, leading to an increased chance of pregnancy. PRP treatments are also advantageous because the process of extracting it is very simple, as only a sample of the patient’s blood is required. Said sample is then processed and centrifuged to separate the component. Once the PRP concentration is obtained, it is divided into several samples and applied under medical advice at different stages of the treatment, before proceeding to the embryo transfer. 

Next, the two possibilities that currently exist for the use of PRP will be discussed: uterine rejuvenation techniques and ovarian rejuvenation techniques. 

Uterine or endometrial rejuvenation techniques

The endometrium, which is the inner layer of the uterus, plays an extremely important role in embryo implantation and embryo development. It must therefore be in optimal condition when seeking to conceive. 

Uterine rejuvenation therapies – also known as endometrial rejuvenation therapies – are focused on enhancing the development of the endometrium and optimising its condition through intrauterine or subendometrial instillations. 

In this context, it should be highlighted that PRP treatments are beneficial in women suffering, for example, from adenomyosis or chronic endometritis, as well as in patients with Asherman’s syndrome or refractory endometrium. 

In recent years, the application of PRP has proven to be equally effective in cases of implantation failure and recurrent pregnancy loss. 

Ovarian rejuvenation techniques

The other therapeutic avenue that regenerative medicine offers is the use of platelet-rich plasma in the ovaries, focused on facilitating ovarian response. This is achieved by stimulating those eggs that are inactive, promoting the maturation of their follicles. 

This treatment is recommended for patients with ovarian failure, low ovarian reserve, hormonal imbalances or for those who have undergone previous unsuccessful in vitro fertilisation cycles, as well as for women with a high rate of oocyte aneuploidy. 

IVF-Life, where state-of-the-art is not just an option

For the professionals at IVF-Life, learning and implementing each innovation and advance that our sector offers has been and always will be an inherent motivation in our know-how, as it is ultimately what has led us throughout our history to achieve success in the treatment of our patients.  

The blend of regenerative medicine and assisted reproduction is here to optimise fertility processes, through techniques that are simple to perform and practically risk-free. Our experts in reproductive medicine will be the ones to bring you closer to these new and promising procedures with the purpose that moves us day after day: achieving pregnancy together.